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A Clinical observation was done on 149 patients admitled with suspect typhoid fever at the Soon chun Hyang University Hospital over a period of 8 years from January 1980 to December 1987. The resul are as follows: 1. There was no significant sexual difference in frequency. The peak age of distribution was in the third and fourth decades, being 51.7% of tatal patients. 2. The clinical manifestations were fever and chill(96.0%), healdache (56.4%), abdominal pain (43.0%), nausea(38.3%), abdominal tenderness(28.2%) hepatomegly(11.4%), in order. 3. Blood culture for S, typhi revealed positive in 26 patients(17.4%). 4. Widal reaction was positive in 73 patients(49.0%). In cases of positive culture in blood, the widal reaction was above 1:160 in 12 patients(46.2%). 5. A leukocyte counts less than 5,000 per cubic millimeter were seen in 34 patients(22.8%) and greater than 10,000 in 30 patients(20.1%). In cases of positive culture in blood, leukopenia was seen in 5 patients(19.2%). 6. Significant elevation of GOT(or GPT) were in 45 patients(30.2%). In cases of positive culture in blood, significant elevation of GOT(or GPT) were in 16 patients(61.5%). 7. The duration for defervescence were within 7 days in 66.2% in patients treated with chloramphenical and in 76.9% with ampicillin.
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